Possible effect of secretor locus on plasma concentration of factor VIII and von Willebrand factor
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منابع مشابه
Possible effect of secretor locus on plasma concentration of factor VIII and von Willebrand factor.
A significant fraction (30%) of the genetically determined variance in plasma concentration of the von Willebrand factor antigen (vWf:Ag) has been shown to be related to ABH determinants. Individuals with blood group O, who have the highest amounts of blood group H substance, have the lowest concentration of vWf:Ag. The Lewis substances, Le(a) and Le(b), are biochemically closely related to the...
متن کاملFainting induces an acute increase in the concentration of plasma factor VIII and von Willebrand factor.
BACKGROUND AND OBJECTIVES von Willebrand factor (VWF) is stored in the Weibel-Palade bodies of endothelial cells and may be released in response to different secretion stimuli such as stress, physical exercise, adrenaline, DDAVP and thrombin. DESIGN AND METHODS We found that fainting can also induce an acute increase in plasma VWF and factor FVIII (FVIII) concentrations, following observation...
متن کاملFactor VIII/von Willebrand factor protein. Galactose a cryptic determinant of von Willebrand factor activity.
The normal Factor VIII/von Willebrand factor protein has the ability to agglutinate or aggregate normal platelets in the presence of ristocetin (von Willebrand factor activity). Removal of greater than 95% of the sialic acid from this protein by neuraminidase did not affect the von Willebrand factor or procoagulant activity. However, oxidation of the penultimate galactose of the asialo Factor V...
متن کاملKinetics of factor VIII-von Willebrand factor association.
The binding of factor VIII to von Willebrand factor (vWF) is essential for the protection of factor VIII against proteolytic degradation in plasma. We have characterized the binding kinetics of human factor VIII with vWF using a centrifugation binding assay. Purified or plasma vWF was immobilized with a monoclonal antibody (MoAb RU1) covalently linked to Sepharose (Pharmacia LKB Biotechnology, ...
متن کاملInteraction of factor VIII-von Willebrand Factor with phospholipid vesicles.
The interaction of Factor VIII-von Willebrand Factor with phospholipid vesicles has been studied by using sucrose-density-gradient ultracentrifugation. When purified Factor VIII-von Willebrand Factor was run alone. Factor VIII activity and Factor VIIIR-Ag sedimented together to the lower half of the tube. Addition of phosphatidylserine/phosphatidylethanolamine vesicles at concentrations above 2...
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ژورنال
عنوان ژورنال: Blood
سال: 1989
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v73.4.990.990